About Calcium Folinate (Leucovorin Calcium)
Class: | Antidote, Chemoprotective agent
Use: | Used to reduce the toxicity of methotrexate, to treat folate deficiency, and as an adjunct in certain cancer therapies (e.g., in combination with fluorouracil for colorectal cancer)
Adult dose: | 15 mg to 30 mg administered intramuscularly or intravenously once daily for 5 to 10 days following high-dose methotrexate therapy; specific dosing may vary based on indication
Pediatric dose: | 0.5 mg to 1 mg/kg administered intramuscularly or intrav
Drug Class
Antidote, Chemoprotective agent
Uses & Indications
Used to reduce the toxicity of methotrexate, to treat folate deficiency, and as an adjunct in certain cancer therapies (e.g., in combination with fluorouracil for colorectal cancer)
Storage Requirements
Store at room temperature (20°C to 25°C or 68°F to 77°F); protect from light and moisture; keep out of reach of children
Manufacturer & Packaging
Manufacturer: Ebewe Pharma, AUSTRIA
Package Size
Blister Pack x 20 tablets
Price & Supplier
Price in UAE: AED 126.79
Dosage Information
Adult Dose
15 mg to 30 mg administered intramuscularly or intravenously once daily for 5 to 10 days following high-dose methotrexate therapy; specific dosing may vary based on indication
Pediatric Dose
0.5 mg to 1 mg/kg administered intramuscularly or intravenously once daily for 5 to 10 days following high-dose methotrexate therapy; maximum dose typically does not exceed adult dosing
Side Effects
Nausea, vomiting, diarrhea, abdominal pain, rash, and allergic reactions
Contraindications & Precautions
Hypersensitivity to calcium folinate or any component of the formulation; should not be used in patients with pernicious anemia or other megaloblastic anemias due to vitamin B12 deficiency
Important Warnings
Use with caution in patients with renal impairment; may mask symptoms of vitamin B12 deficiency; monitor for signs of allergic reactions; not to be used as a substitute for adequate vitamin B12 therapy in patients with deficiency
Related Medicines in Same Category
See also: Other Antidote, Chemoprotective agent medicines available in UAE pharmacies
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Medical Disclaimer
This information is for educational purposes only and should not replace professional medical advice.
Always consult with a licensed healthcare provider or pharmacist in the UAE before taking any medication.
The information presented here is specific to medicines available in UAE pharmacies and is regularly updated
to ensure accuracy for patients and healthcare professionals in the United Arab Emirates.